Pathomechanism of Bone Mineral Density Decrease: A study of Role of Low Density Lipoprotein (LDL), Oxidized Low Density Lipoprotein (oxLDL) and Receptor For Activation of Nuclear Factor Kappa β Ligand (RANKL)


  • Sitti Rafiah, Irene Edith Rieuwpassa, Uleng Bahrun


The research aimed to investigate the role of LDL, oxLDL and RANKL on the Bone Mineral Density Decrease The research use thecross sectional study of 78 women 30-60 years old who had the fasting blood glucose content, SGOT/SGPT, urea creatinine normal. Method used to assess the bone mineral density decrease was by using Dual Energy X-ray absorptiometry (DXA) which was measured on the lumbar spine and proximal femur, whereas the measurement of LDL content by the photometry method using Petra 400 equipment, the measurement of oxLDL content and RANKL content using ELISA method. The data collected were processed by Mann-Whitney U test and chi-square test to perceive the difference on the normal bone mineral density group, osteopeni and osteoporosis. The research results indicated that the LDL content is not  different on the three groups of bone mineral density (p>0.05), whereas the oxLDL content is not  different between the normal group and osteopeni group (p>0.05), however, it is  different between the normalgroup and osteoporosis group (p<0,05) and between osteopeni group and osteoporosis group (p<0,05). So is RANKL content is different between the groups (p<0.05) except between the osteopeni and osteoporosis (p>0,05). The data suggests a role of oxLDL and RANKL on decrease of bone mineral density.We concluded that oxLDL and RANKL contributes to decrease of bone mineral density, but otherwise LDL cholesterol to contribute does not significantly to decreased in bone mineral density.