Assessment of Human Serum Interleukin-6 (IL-6) and Interleukin-10 ( IL-10)in Cutaneous Leishmaniasis Patients in Anbar Governorate


  • Khalid K. Addi, Wajeeh Y. Alani, Abdullah S. Hasan


Cutaneous leishmaniasis, sandflies, cytokines, interleukin, anti-inflammatory, immune response


Background: Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis.There are two forms  of  CL in Iraqzoonotic (ZCL) and anthroponotic CL (ACL) are caused by two species  of  Leishmania  protozoa (L. major and  L. tropica) that are transmitted  by sandflies (Phlebotomus), as  biological vectors  that spread the disease to humans.The aim of studyis to evaluate the effect of some immunevariables inCLpatient in  Al Anbar governoratesuch as(IL-6 , IL-10) thenknow how to  effect this  cytokines  on the progress of the disease or  healing. Methods: The study includes 80 blood samples of  CL  patients ( 45 males  and 35 females) and 60 blood samples from healthy individuals ( 32 males   and 28 females) as control group,  the date of sampling persists from January 2021 up to  March 2021.Specimen of  patients  and  healthy individuals  are  dividedaccording to the  sexto  males  and  females.Results:The immunological  study  for  the  patients  serums with  CLby ELISA technique has significantly shown raised  values of  IL-6 in the serum of  patient's  group  during  infection  in comparison with the control group  ( P ≤ 0.001 ) . On  the  other hand  the  concentrations  of IL-10 in the patient's  group was  significantly  lower than those  ofcontrol  group ( P ≤ 0.05 ).Conclusion: IL-6 is significantly increase in CL patient of Al-Anbargovernorate , compared with control group, there is relationship between the IL-6 and CL disease.The level ofthe IL-10 decreased significantly during CL diseasesthere is a relationship between the IL-10 and CL disease.