Assessment of Human Serum Interleukin-6 (IL-6) and Interleukin-10 ( IL-10)in Cutaneous Leishmaniasis Patients in Anbar Governorate
Keywords:Cutaneous leishmaniasis, sandflies, cytokines, interleukin, anti-inflammatory, immune response
Background: Cutaneous leishmaniasis (CL) is the most common form of leishmaniasis.There are two forms of CL in Iraqzoonotic (ZCL) and anthroponotic CL (ACL) are caused by two species of Leishmania protozoa (L. major and L. tropica) that are transmitted by sandflies (Phlebotomus), as biological vectors that spread the disease to humans.The aim of studyis to evaluate the effect of some immunevariables inCLpatient in Al Anbar governoratesuch as(IL-6 , IL-10) thenknow how to effect this cytokines on the progress of the disease or healing. Methods: The study includes 80 blood samples of CL patients ( 45 males and 35 females) and 60 blood samples from healthy individuals ( 32 males and 28 females) as control group, the date of sampling persists from January 2021 up to March 2021.Specimen of patients and healthy individuals are dividedaccording to the sexto males and females.Results:The immunological study for the patients serums with CLby ELISA technique has significantly shown raised values of IL-6 in the serum of patient's group during infection in comparison with the control group ( P ≤ 0.001 ) . On the other hand the concentrations of IL-10 in the patient's group was significantly lower than those ofcontrol group ( P ≤ 0.05 ).Conclusion: IL-6 is significantly increase in CL patient of Al-Anbargovernorate , compared with control group, there is relationship between the IL-6 and CL disease.The level ofthe IL-10 decreased significantly during CL diseasesthere is a relationship between the IL-10 and CL disease.