Uterine Fibroids - A Systematic Analysis of Biochemical Factors
Keywords:
Uterine fibroids, Vitamin D, Calcium, Oxidative stressAbstract
Background: Uterine Fibroids are the commonest uterine smooth muscle tumors. Many causative factors are involved in the etio pathogenesis including the female reproductive hormones otherwise called as uterine steroid hormones-estrogen and progesterone, positive family history among first degree relatives, age, parity, ethinicity etc. The prevalence rate is 30-50% in women in the reproductive age group.
Aims and objectives: To analyze the biochemical parameters along with vitamin D and oxidative stress marker, Malondialdehyde (MDA) in uterine fibroid cases and to compare the same with apparently healthy study subjects.
Materials and methods: 103 uterine fibroid cases and 83 age matched controls were studied for their biochemical parameters including lipid profile, liver function tests, vitamin D, complete blood count, blood grouping and Plasma MDA.
Results: Patients with uterine fibroids had earlier age of menarche and first child birth when compared to normal subjects. They were anaemic with low hemoglobin Hb (gm %) 8.95 ± 1.83 against controls 11.3 ± 0.51. Their HDL (mg/dl) was low with mean value 41.8 ± 5.6 compared to control values (49.4±3.8). In liver function tests, alkaline phosphatase(IU/L) was significantly elevated 156.7 ± 64.2 IU/L when compared to the controls with mean value of 83.2 ±15.11 IU/L. Vitamin D was significantly lower in the cases than the controls with mean value of 36.89± 8.46. Uterine fibroid patients have increased oxidative stress level than their counterparts. They were hyperestrogenic with 125.45± 97.9 & 52.31±13.71 mean value respectively among cases and controls.
Conclusion: Uterine fibroids are more common in the reproductive age group especially in women between 30-50 years of age. Most of the patients were anemic, hypocalcaemic with significant low vitamin D level and increased oxidatively stressed when compared to the controls with predominant B positive blood group with significant difference in their hormonal status.